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. Author manuscript; available in PMC: 2015 May 27.
Published in final edited form as: Nat Commun. 2014 Nov 27;5:5588. doi: 10.1038/ncomms6588

Figure 4. FGF signaling regulates Bmp4 expression, as well as noggin2 and gremlin1a, two BMP antagonists.

Figure 4

(A–C) bmp4 expression is altered following manipulation of FGF signaling. bmp4 levels of expression are increased in hsp70:dn-fgfr1 embryos (B and E) and decreased in hsp70:ca-fgfr1 embryos (C and F). (D–F) Transverse sections of embryos from WISH samples (A–C). (G–I) Schematic representing bmp4 expression in control (G), hsp70:dn-fgfr1 (H), and hsp70:ca-fgfr1 (I) embryos. (J–O) gremlin1a (J–L) and noggin2 (M–O) expression is reduced in hsp70:dn-fgfr1 embryos (K and N), and enhanced in hsp70:ca-fgfr1 embryos (L and O). M: mesenchyme. Scale bars: (A) 200um, (D) 50um.