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. Author manuscript; available in PMC: 2015 May 27.
Published in final edited form as: Nat Commun. 2014 Nov 27;5:5588. doi: 10.1038/ncomms6588

Figure 6. Ectopic activation of BMP signaling rescues runx1 expression in an activated FGF background.

Figure 6

(A–D) runx1 expression increases in the DA following activation of the BMP pathway (C), compared to controls (A). runx1 expression in hsp70:ca-fgfr1 (B) embryos is rescued by activation of a hse:cabmpr1b transgene (D). Quantitative analysis of runx1 expression (E). pea3 expression in the head (inserts, A–D) is upregulated upon FGF activation. (F–K) runx1 expression is impaired upon overexpression of either gremlin1a (H) or noggin2 (J) compared to control (F). Inhibition of FGF signaling fails to rescue runx1 expression when gremlin1a (I) and noggin2 (K) are overexpressed. Scale bars: (A, F) 200um.