Table 1.

Clinical and CCTA descriptors of 7,200 symptomatic patients by CAC score

	CAC 0 (n = 4,047) (%)	CAC 1–10 (n = 524) (%)	CAC 11–100 (n = 1,300) (%)	CAC 101–399 (n = 823) (%)	CAC ≥ 400 (n = 384) (%)	P value
Age (in deciles)						<.0001
<40	13.7	4.8	3.2	5.3	7.0
40–49	24.9	20.0	14.5	12.9	11.0
50–59	32.8	28.4	29.7	24.6	19.1
60–69	21.6	31.1	33.6	30.7	29.8
70–79	6.2	13.2	15.9	20.7	24.0
≥80	0.8	2.5	3.1	5.8	9.2
Female gender	57.5	47.8	48.9	49.1	44.1	<.0001
Risk factors
Hypertension	44.9	50.1	56.9	53.9	58.5	<.0001
Diabetes	9.5	13.4	15.7	15.3	19.0	<.0001
Dyslipidemia	51.6	59.4	59.8	57.4	54.5	<.0001
Family history	27.1	28.8	32.3	31.3	34.4	<.0001
Smoker	16.0	20.7	14.7	15.0	17.3	.62
Obesity	20.7	28.9	29.1	31.1	31.4	<.0001
Chest pain						<.0001
Dyspnea	7.8	11.4	11.7	15.2	17.0
Non-cardiac	11.1	8.3	10.4	10.1	6.9
Atypical	65.8	65.0	61.9	60.0	63.6
Typical	15.3	15.3	15.9	14.7	12.5
Mild stenosis on CCTA
Left main	1.8	10.6	13.6	20.6	27.7	<.0001
Proximal LAD	7.9	34.9	50.3	58.3	62.8	<.0001
Proximal RCA	3.1	11.8	19.0	30.5	45.5	<.0001
Proximal left Cx	1.9	8.2	14.2	23.6	43.8	<.0001
Medication use
Aspirin	32.2	43.9	52.7	52.7	61.7	<.0001
Statins	23.3	38.2	43.0	52.1	48.5	<.0001
Hyperglycemics	4.0	5.9	8.1	8.1	9.4	<.0001
Insulin	0.5	0.8	1.3	1.9	3.1	<.0001
ACE inhibitor	8.6	17.1	17.0	18.6	23.4	<.0001
Beta-blockers	22.6	30.7	31.9	32.7	44.9	<.0001
CCD	16.9	23.9	26.6	25.4	26.0	<.0001
Nitrates	13.0	12.8	15.6	13.5	21.7	.004

Available data for medications: aspirin (n = 5,294), statins (n = 4,891), hyperglycemics (n = 5,056), insulin (n = 5,064), ACE inhibitor (n = 5,295), beta-blockers (n = 5,295), CCB (n = 5,081), nitrates (n = 5,050).

LAD, Left anterior descending; RCA right coronary artery; Cx, circumflex; ACE, angiotensin converting enzyme; CCB, calcium channel blocker.