Table 1.

Clinical characteristics of sequenced cohort

	Case 1a	Case 2a	Case 3	Case 4	Case 5	Case 6	Case 7	Case 8	Case 9	Case 10
Age	26	20	60	51	40	57	30	41	21	47
Gender	M	M	F	F	M	M	F	M	F	M
Race, ethnicity	Asian	Asian	White	White	Latino	White	White	White	Asian	White
Days from onset to enrollment	6	8	24	7	9	8	50	13	9	11
History of liver disease	no	no	no	no	no	no	no	no	no	no
Anti-HAV IgM	+	+	+	+	+	+	+	+	+	+
INR > 1.5	yes	yes	yes	yes	yes	yes	yes	yes	yes	yes
Altered mental status	yes	no	yes	yes	yes	yes	yes	yes	yes	yes
Peak encephalopathy grade	III	0b	IV	IV	IV	IV	I	II	III	III
Outcome	Transplant	Spontaneous survival	Transplant	Spontaneous survival	Spontaneous survival	Transplant	Transplant	Transplant	Spontaneous survival	Transplant

nd = no data

^afirst cousins

^bnot encephalopathic (acute liver injury)