Table 3. Increased expression of Mφ genes exclusively in prepartum D21 rat cervix (p<0.01; n = 3/group).
| Symbol | Entrez Gene Name | Function | Fold |
|---|---|---|---|
| FCN1 | Ficolin 1 (collagen/fibrinogen domain) | Collagen-like domain, lectin activity; Clusters 2 & 8; ECM | 77 |
| GPR34 | G protein-coupled receptor 34 | Cell Signaling; SIG | 68 |
| CD206 | Mannose receptor, C type 1 | Cluster 2; ECM | 67 |
| CD300C | CD300c molecule | On specific immune cells & cell lines | 57 |
| MS4A4A | Membrane-spanning 4-domains, subfam A | Cluster 2 | 44 |
| CD163 | CD163 molecule | Scavenger receptor activity; Cluster 2 | 39 |
| F13A1 | Coagulation factor XIII, A1 polypeptide | Involved in wound healing; Cluster 2; ECM | 32 |
| PTPRC | Protein tyrosine phosphatase, receptor type C | Humoral&cell-mediated immunity; Cluster 1; ECM | 30 |
| RGS18 | Regulator of G-protein signaling 18 | Signal Transduction Inhibition; SIG | 28 |
| CPA3 | Carboxypeptidase A3 (mast cell) | Catalyst of C-terminal amino acid release | 27 |
| Mcpt1 | Mast cell protease 1 | Chymotripsin-like activity, INFL | 27 |
| EVI2A | Ecotropic viral integration site 2A | Membrane complex protein receptor, Cluster 1 | 24 |
| HLA-DRB1 | MHCII, DR beta 1 | Chronic inflammation; INFL | 22 |
| CCR2 | Chemokine (C-C motif) receptor 2 | MCP-1, -3, -4 chemokines; Cluster 1; INFL | 22 |
| FAIM3 | Fas apoptotic inhibitory molecule 3 | Apoptosis protection and immune system processes; Cluster 2; INFL | 18 |
| NMUR2 | Neuromedin U receptor 2 | Selective Neuropeptide Receptor | 16 |
| SMOC1 | SPARC related modular calcium binding 1 | Eye and Limb development Regulation | 15 |
| SLC11A1 | Solute carrier family 11 member 1 | Iron and Manganese Transporter | 15 |
| ARL11 | ADP-ribosylation factor-like 11 | Tumor suppression, apoptosis | 14 |
| TLR7 | Toll-like receptor 7 | Innate immune response via cytokine secretion and inflammatory responses; INFL | 13 |
| PPYR1 | Pancreatic polypeptide receptor 1 | Selective Neuropeptide Receptor | 13 |
| BCMO1 | Beta-carotene 15,15'-monooxygenase 1 | Enzyme Responsible for Retinal Formation | 12 |
| COCH | Coagulation factor C homolog, cochlin (L. polyphemus) | Cell Shape and Motility | 12 |
| PRKCB | Protein kinase C, beta | Phorbol esters receptor (tumor promoters); Cluster 13; SIG | 12 |
| MPEG1 | Macrophage expressed 1 | Expressed in macrophages. | 12 |
| MYO1F | Myosin IF | Intracellular movement; Cluster 1; ECM | 12 |
| MYO1G | Myosin IG | Intracellular Movements; ECM | 11 |
| TPSAB | Tryptase alpha/beta 1 | ECM | 10 |
| SYNPO2 | Synaptopodin 2 | Actin Binding and Bundling; ECM | 10 |
| AOAH | Acyloxyacyl hydrolase (neutrophil) | Removes secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial LPS | 10 |
| BTK | Bruton agammaglobulinemia tyrosine kinase | B cell maturation | 10 |
| COL4A5 | Collagen, type IV, alpha 5 | Type IV collagen formation in glomeruli structure; Cluster 6; SIG | 10 |
Function designations in rat derived from DAVID (http://david.abcc.ncifcrf.gov), Biolayout Express 3D cluster analyses, and IPA (ECM = extracellular matrix, INFL = inflammation, SIG = Signaling).