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. 2015 Mar 26;10(3):e0117479. doi: 10.1371/journal.pone.0117479

Fig 7. TOX stimulated MF cell proliferation and invasion through AKT phosphorylation.

Fig 7

(A) Western blot assays showed that LY294002 can inhibited AKT phosphorylation. The expression of p-AKT was normalized to GAPDH. (B) Western blot assays showed that overexpression of TOX stimulated AKT phosphorylation. The expression of p-AKT was normalized to GAPDH. (C) The proliferative role of TOX overexpression was largely blocked by LY294002, an AKT inhibitor, in MyLa cells were transfected with TOX vector, control or not transfected or TOX vector and LY294002. (D) The invasive role of TOX overexpression was largely blocked by LY294002, an AKT inhibitor, in MyLa cells were transfected with TOX vector, control or not transfected or TOX vector and LY294002. ** p<0.01, *p<0.05, and ***p<0.001.