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. 2015 Mar 26;10(3):e0119842. doi: 10.1371/journal.pone.0119842

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© 2015 Zhivov et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 1 — Case 1: 62-year-old male patient, DM duration 9 years, HbA_1c 6.5%, NDS 4 points; Wagner 1 (a), no signs of DR (b), normal SBP morphology (NFD = 0.011 μm/μm²) (c). Case 2: 62-year-old female patient, DM duration 7 years, HbA_1c 9.4%, NDS 5 points; Wagner 2 (d), advanced non-proliferative DR (e), moderate decrease in confocal SBP parameters (NFD = 0.010 μm/μm²) (f). Case 3: 44-year-old female patient, DM duration 9 years, HbA_1c 11%, NDS 9 points; Wagner 5 (g), proliferative DR with retinal detachment (h), moderate decrease in confocal SBP parameters (NFD = 0.011 μm/μm²) (i). Case 4: 59-year-old female patient, DM duration 31 years, HbA_1c 10.4%, NDS 6 points; Wagner 0 (k), proliferative DR (l), moderate decrease in confocal SBP parameters (NFD = 0.008 μm/μm²) (m). Case 5: 58-year-old female patient, DM duration 12 years, HbA_1c 8.2%, NDS 5 points; Wagner 5 (n), no signs of DR (o), normal SBP morphology (NFD = 0.014 μm/μm²) (p)