Table 3.

Multivariate Analysis of Independent Contributors to Illness Progression^a

Variable	Odds Ratio	SE	z	P	95% CI
Physical or sexual abuse	1.11	0.32	0.38	.71	0.63–1.96
Verbal abuse	1.35	0.38	1.07	.28	0.78–2.34
Age at onset	1.62	0.44	1.80	.07	0.96–2.75
Anxiety disorder	1.36	0.36	1.19	.23	0.82–2.27
Substance abuse	1.57	0.40	1.80	.07	0.96–2.58
Rapid cycling	2.80	0.80	3.61	0	1.60–4.91
> 20 Episodes	1.46	0.42	1.32	.19	0.83–2.58
Body mass index (kg/m2) > 26	0.92	0.23	0.34	.73	0.56–1.51
> 2 Comorbidities	1.22	0.32	0.77	.44	0.73–2.03
Poor social support	1.18	0.31	0.63	.53	0.71–1.97
Poor health care	1.32	0.41	0.91	.36	0.72–2.42
Poor employment	1.32	0.35	1.05	.3	0.79–2.21
Family history of depression	1.18	0.30	0.65	.52	0.72–1.94
Family history of mania	0.95	0.26	0.19	.85	0.55–1.63
Delay to treatment > 3 y	1.65	0.45	1.85	.07	0.97–2.82

^aA logistic regression found poor prognosis factors successfully predicted illness progression (likelihood ratio χ² = 96.46, P < .001, pseudo R² = 0.1809, n = 480). A P value of zero equals P < .001.