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Synthesis of bivalent ligand 1a
a Regents and conditions: (a) CbzCl, DCM, MeOH, 5 °C, 32%; (b) THF, diglycolic anhydride, rt, 85%; (c) EDCI, HOBt, TEA, 4·2HCl, 4Å MS, DMF, 0 °C to rt, 76%; (d) 10% Pd/C, 60 psi, MeOH, 99%; (e) DMF, diglycolic anhydride, rt, 82%; (f) EDCI, HOBt, TEA, 6, 4Å MS, DMF, 0 °C to rt, 50%.
