Table 3. Association of well-being with gene expression: pooled Discovery and Confirmation Studies.
| Well-being dimension | Association b ± SE 1 | Test statistic | p-value | VIF 2 | |
|---|---|---|---|---|---|
| A. 2-dimensional | |||||
| Hedonic well-being | 0.074 ± 0.042 | t(179) = 1.77 | .0781 | 2.44 | |
| Eudaimonic well-being | -0.116 ± 0.043 | t(179) = -2.71 | .0074 | 2.54 | |
| B. 3-dimensional | |||||
| Hedonic well-being | 0.059 ± 0.042 | t(178) = 1.39 | .1663 | 2.53 | |
| Psychological well-being | 0.015 ± 0.052 | t(178) = 0.29 | .7702 | 3.82 | |
| Social well-being | -0.126 ± 0.045 | t(178) = -2.81 | .0055 | 2.83 | |
| C. 1-dimensional | |||||
| Total well-being | -0.050 ± 0.028 | t(180) = -1.78 | .0775 | 1.07 | |
| D. Categorical | |||||
| Flourishing mental health | -0.051 ± 0.056 | t(180) = -0.91 | .3637 | 1.06 | |
1. Partial regression coefficients relating standardized gene expression values to standardized scores on 1-, 2-, and 3-d representations of well-being (A, B, C) or a categorical representation of flourishing mental health (D). All associations are adjusted for age, sex, race, BMI, smoking, alcohol consumption, illness symptoms, and gene transcript covariates marking major leukocyte subsets.
2. Variance Inflation Factor. Values > 10 indicate significant multicollinearity.