Table 5. Association of psychological well-being with gene expression: Generalization Study.
| Well-being dimension | Association b ± SE 1 | Test statistic | p-value | VIF 2 | |
|---|---|---|---|---|---|
| A. 1-dimensional | |||||
| Total psychological well-being | -0.0087 ± 0.0021 | t(88) = -4.17 | <. 0001 | 1.18 | |
| B. 6-dimensional (independent) | |||||
| Purpose in life | -0.0071 ± 0.0021 | t(88) = -3.40 | .0010 | 1.18 | |
| Environmental mastery | -0.0070 ± 0.0021 | t(88) = -3.37 | .0011 | 1.15 | |
| Self-acceptance | -0.0112 ± 0.0021 | t(88) = -5.26 | <. 0001 | 1.29 | |
| Autonomy | -0.0057 ± 0.0021 | t(88) = -2.66 | .0093 | 1.22 | |
| Personal growth | 0.0019 ± 0.0021 | t(88) = 0.87 | .3881 | 1.17 | |
| Positive relations with others | -0.0061 ± 0.0021 | t(88) = -2.85 | .0055 | 1.21 | |
| C. 6-dimensional (mutually adjusted) | |||||
| Purpose in life | -0.0045 ± 0.0024 | t(83) = -1.85 | .0681 | 1.92 | |
| Environmental mastery | 0.0026 ± 0.0028 | t(83) = 0.90 | .3704 | 2.66 | |
| Self-acceptance | -0.0147 ± 0.0029 | t(83) = -4.98 | <. 0001 | 2.87 | |
| Autonomy | -0.0082 ± 0.0021 | t(83) = -3.89 | .0002 | 1.46 | |
| Personal growth | 0.0159 ± 0.0025 | t(83) = 6.31 | <. 0001 | 2.10 | |
| Positive relations with others | -0.0051 ± 0.0023 | t(83) = -2.23 | .0282 | 1.70 | |
1. Partial regression coefficients relating centered log2 gene expression values to standardized scores on 1- or 6-d representations of psychological well-being. All associations are adjusted for age, sex, race, BMI, smoking, alcohol consumption, and gene transcript covariates marking major leukocyte subsets.
2. Variance Inflation Factor. Values > 10 indicate significant multicollinearity.