Table 2. Clinical and biological characteristics among LPL rs301, rs328 and rs13702 Genotypes.
| rs301 TT | rs301 TC/CC | ||||
|---|---|---|---|---|---|
| Characteristic | n | % | n | % | p a |
| No of patients | 146 | 59.1 | 101 | 40.9 | |
| HWE c | 58.0 | 42.0 | 0.322 | ||
| Gender | |||||
| Male | 100 | 59.2 | 69 | 40.8 | 1.000 |
| Female | 46 | 59.0 | 32 | 41.0 | |
| Median age at diagnosis | 63 | 62 | 0.651 b | ||
| Age | |||||
| <60 years | 59 | 60.8 | 38 | 39.2 | 0.786 |
| ≥60 years | 85 | 58.2 | 61 | 41.8 | |
| Binet stage | |||||
| A | 106 | 57.9 | 77 | 42.1 | 0.404 |
| B/C | 31 | 66.0 | 16 | 34.0 | |
| IGHV | |||||
| Mutated | 74 | 58.7 | 52 | 41.3 | 0.972 |
| Unmutated | 48 | 60.0 | 32 | 40.0 | |
| CD38 | |||||
| <7% | 68 | 54.8 | 56 | 45.2 | 0.224 |
| ≥7% | 65 | 63.7 | 37 | 36.3 | |
| ZAP70 | |||||
| <20% | 75 | 60.5 | 49 | 39.5 | 1.000 |
| ≥20% | 54 | 61.4 | 34 | 38.6 | |
| LPL | |||||
| negative | 62 | 63.3 | 36 | 36.7 | 0.821 |
| positive | 57 | 60.6 | 37 | 39.4 | |
| LDT | |||||
| ≥ 1 year | 71 | 61.2 | 45 | 38.8 | 0.662 |
| < 1 year | 55 | 57.3 | 41 | 42.7 | |
| Cytogenetics | |||||
| normal | 36 | 61.0 | 23 | 39.0 | 0.590 |
| chromosomal aberrations | 87 | 55.8 | 69 | 44.2 | |
| Del13q | |||||
| absent | 68 | 63.6 | 39 | 36.4 | 0.232 |
| present | 51 | 54.3 | 43 | 45.7 | |
| Del11q | |||||
| absent | 109 | 58.3 | 78 | 41.7 | 0.606 |
| present | 11 | 50.0 | 11 | 50.0 | |
| Del17p | |||||
| absent | 106 | 55.5 | 85 | 44.5 | 0.563 |
| present | 13 | 65.0 | 7 | 35.0 | |
| rs328 CC | rs328 CG/GG | ||||
| Characteristic | n | % | n | % | P a |
| No of patients | 195 | 78.6 | 53 | 21.4 | |
| HWE c | 77.9 | 22.2 | 0.123 | ||
| Gender | |||||
| Male | 134 | 78.8 | 36 | 21.2 | 1.000 |
| Female | 61 | 78.2 | 17 | 21.8 | |
| Median age at diagnosis | 62 | 62 | 0.878 b | ||
| Age | |||||
| <60 years | 79 | 80.6 | 19 | 19.4 | 0.752 |
| ≥60 years | 114 | 78.1 | 32 | 21.9 | |
| Binet stage | |||||
| A | 144 | 78.3 | 40 | 21.7 | 0.610 |
| B/C | 39 | 83.0 | 8 | 17.0 | |
| IGHV | |||||
| Mutated | 104 | 81.9 | 23 | 18.1 | 0.421 |
| Unmutated | 61 | 76.3 | 19 | 23.8 | |
| CD38 | |||||
| <7% | 99 | 79.8 | 25 | 20.2 | 0.954 |
| ≥7% | 81 | 78.6 | 22 | 21.4 | |
| ZAP70 | |||||
| <20% | 99 | 79.2 | 26 | 20.8 | 0.867 |
| ≥20% | 68 | 77.3 | 20 | 22.7 | |
| LPL | |||||
| negative | 83 | 84.7 | 15 | 15.3 | 0.483 |
| positive | 75 | 79.8 | 19 | 20.2 | |
| LDT | |||||
| ≥ 1 year | 92 | 79.3 | 24 | 20.7 | 1.000 |
| < 1 year | 77 | 79.4 | 20 | 20.6 | |
| Cytogenetics | |||||
| Normal | 46 | 78.0 | 13 | 22.0 | 1.000 |
| Chromosomal aberrations | 123 | 78.3 | 34 | 21.7 | |
| Del13q | |||||
| absent | 85 | 78.7 | 23 | 21.3 | 1.000 |
| present | 74 | 78.7 | 20 | 21.3 | |
| Del11q | |||||
| absent | 150 | 79.8 | 38 | 20.2 | 0.144 |
| present | 14 | 63.6 | 8 | 36.4 | |
| Del17p | |||||
| Absent | 149 | 77.6 | 43 | 22.4 | 0.316 |
| Present | 18 | 90.0 | 2 | 10.0 | |
| rs13702 TT | rs13702 TC/CC | ||||
| Characteristic | n | % | n | % | p a |
| No of patients | 123 | 50.0 | 123 | 50.0 | |
| HWE c | 49.1 | 50.9 | 0.413 | ||
| Gender | |||||
| Male | 87 | 51.5 | 82 | 48.5 | 0.582 |
| Female | 36 | 46.8 | 41 | 53.2 | |
| Median age at diagnosis | 63 | 62 | 0.501 b | ||
| Age | |||||
| <60 years | 48 | 49.5 | 49 | 50.5 | 1.000 |
| ≥60 years | 73 | 50.3 | 72 | 49.7 | |
| Binet stage | |||||
| A | 87 | 47.8 | 95 | 52.2 | 0.202 |
| B/C | 28 | 59.6 | 19 | 40.4 | |
| IGHV | |||||
| Mutated | 61 | 48.8 | 64 | 51.2 | 0.369 |
| Unmutated | 45 | 56.3 | 35 | 43.8 | |
| CD38 | |||||
| <7% | 58 | 47.5 | 64 | 52.5 | 0.551 |
| ≥7% | 54 | 52.4 | 49 | 47.6 | |
| ZAP70 | |||||
| <20% | 62 | 50.0 | 62 | 50.0 | 0.663 |
| ≥20% | 47 | 54.0 | 40 | 46.0 | |
| LPL | |||||
| negative | 49 | 50.5 | 48 | 49.5 | 0.877 |
| positive | 49 | 52.7 | 44 | 47.3 | |
| LDT | |||||
| ≥ 1 year | 61 | 53.5 | 53 | 46.5 | 0.298 |
| < 1 year | 44 | 45.4 | 53 | 54.6 | |
| Cytogenetics | |||||
| Normal | 29 | 50.0 | 29 | 50.0 | 1.000 |
| Chromosomal aberrations | 77 | 49.4 | 79 | 50.6 | |
| Del13q | |||||
| absent | 55 | 51.4 | 52 | 48.6 | 0.968 |
| present | 49 | 52.7 | 44 | 47.3 | |
| Del11q | |||||
| absent | 96 | 51.6 | 90 | 48.4 | 0.126 |
| present | 7 | 31.8 | 15 | 68.2 | |
| Del17p | |||||
| absent | 93 | 48.9 | 97 | 51.1 | 0.920 |
| present | 9 | 45.0 | 11 | 55.0 | |
a Cross-tabulations of prognostic markers versus LPL SNP genotypes. p values of Pearson χ² statistics (with the Yates continuity correction for 2x2 tables)
b p value of Mann-Whitney non parametric test comparing median age at diagnosis between LPL SNP genotypes
c HWE, Hardy-Weinberg equilibrium