Table 1. High throughput screen results.

		Molecular Screening Shared Resource (UCLA)	The Scripps Research Institute, Florida
Primary screen	Compounds tested	86,259 compounds at 10 μM	358,484 compounds at 7.35 μM
	Avg. Z’-factor	0.94 ±. 03 a	0.90 ±. 01 b
	Avg. Z-factor	0.64 ± 0.38 a	0.76 ± 0.38 b
	hits c	202 hits = 0.2%	1435 hits = 0.4%
Confirmation and counter- screens	confirmed	78 confirmed	630 confirmed
	quenchers	(7 quenchers)	(93 quenchers)
	Biotin analogs	(4 biotin analogs)	(11 biotin analogs)
	IC 50 < 10 μM	11 active	82 active
	Selected for further analysis	3 compounds	21 compounds

^a n = 254 plates

^b n = 296 plates

^c hits were identified by Z-score ≤-3 computed on a per plate basis.