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. 2015 Mar 26;10(3):e0120998. doi: 10.1371/journal.pone.0120998

Fig 2. Abnormal distribution of kinesin-1 motor protein in cystinosin-deficient cells.

Fig 2

(a) Control and CTNS KD HK-2 cells were fixed and stained with antibodies specific to KIF5b, a component of kinesin-1 complex, and LAMP1. CTNS KD cells had an abnormal distribution of kinesin-1 to LAMP1-positive enlarged structures. Scale bar = 10 μm. (b) Co-localization analysis was performed using ImageJ JACoP plug-in on 50 control and CTNS KD cells. CTNS KD cells had a 8-fold increase of co-localization between KIF5b and LAMP1 (*** p<0.001).