Table 1.
Demographic and clinical characteristics of Study Cohort
Factor | Cholangiocarcinoma (CCA) N=11 |
Primary Sclerosing Cholangitis (PSC) N=21 |
p- value (PSC VS CCA) |
---|---|---|---|
Male, N (%) | 7(63.6%) | 11(52.4%) | 0.71 |
Caucasian, N (%) | 9(81.8%) | 17(85%) | 0.53 |
Body mass index, Mean (SD) | 27.26(9.5) | 25.1(5.0) | 0.97 |
Albumin median [interquartile range] (g/dL) | 3.4(2.9–4.4) | 3.5(3.0–4.1) | 0.77 |
Bilirubin median [interquartile range] (mg/dL) | 2.2(0.8–10.3) | 1.8(0.5–3.4) | 0.41 |
Concomitant Inflammatory bowel disease (IBD) | 2 (18.2%) | 12 (57.1%) | 0.03 |
Current Smoking | 3 (27.3%) | 3 (14.3%) | 0.39 |
Current alcohol use | 2 (18.2%) | 1 (4.8%) | 0.27 |
Distribution of PSC | |||
Intrahepatic | 0 | 4 (19%) | |
Extrahepatic | 2 (18.2%) | 4 (19%) | 0.10 |
Both | 9 (81.8%) | 13 (61.9%) | |
Alkaline phosphatase median [interquartile range] (U/L) | 414(225.5–709.5) | 227.5(154.8–475.5) | 0.27 |
Aspartate aminotransferase median [interquartile range] (U/L) | 93(26.5–127) | 75.5(32.3–101) | 0.74 |
Alanine aminotransferase median [interquartile range] (U/L) | 89(34.5–107.5) | 58(40–113) | 0.91 |
Carbohydrate antigen 19-9 (CA 19-9), U/L, mean (SD) | 250.2 (114.6) | 162.6 (58.1) | 0.14 |