Skip to main content
. 2014 Nov 4;64(4):1211–1223. doi: 10.2337/db14-0539

Figure 5.

Figure 5

The Sesn3 effects in AMPK-deficient mice. A: Fasting blood glucose measurements in WT and AMPKα1,2 liver-specific double knockout (AMPK-LDKO) mice (n = 6–8) infected with GFP- or Sesn3-expressing adenoviruses after overnight starvation with free access to water. Data are presented as mean ± SEM. **P < 0.01 for WT + Sesn3 vs. WT + GFP; ##P < 0.01 for LDKO + GFP vs. LDKO + Sesn3. B: Hepatic triglyceride (TG) measurements in GFP- or Sesn3-expressing adenovirus-infected WT or AMPK-LDKO mice (n = 6–8). Data are presented as mean ± SEM. *P < 0.05 for WT + Sesn3 vs. WT + GFP; #P < 0.05 for LDKO + GFP vs. WT + GFP; ***P < 0.001 for LDKO + Sesn3 vs. WT + Sesn3. C: Glucose tolerance tests in GFP- or Sesn3-expressing adenovirus-infected WT or AMPK-LDKO mice (n = 6–8). Data are presented as mean ± SEM. ***P < 0.001 for WT + Sesn3 vs. WT + GFP; #P < 0.05, ##P < 0.01, and ###P < 0.001 for LDKO + GFP vs. LDKO + Sesn3; §P < 0.05 for LDKO + GFP vs. WT + GFP. D: Insulin tolerance tests in GFP- or Sesn3-expressing adenovirus-infected WT or AMPK-LDKO mice (n = 6–8). Data are presented as mean ± SEM. **P < 0.01 and ***P < 0.001 for LDKO + Sesn3 vs. LDKO + GFP; #P < 0.05 and ###P < 0.001 for WT + Sesn3 vs. WT + GFP. E and F: Insulin signaling analysis in the livers of WT or AMPK-LDKO mice infected with GFP- or Sesn3-expressing adenoviruses without (E) or with (F) insulin stimulation.