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Proposed model for hepatic sestrin actions in the insulin-sensitive and insulin-resistant states. The schematic diagrams depict the role of hepatic sestrins in glucose and lipid homeostasis in insulin-sensitive (left panel) and insulin-resistant states (right panel). DNL, de novo lipogenesis; FoxO, forkhead box O transcription factor; HGP, hepatic glucose production; SREBP-1, sterol regulatory element binding protein 1.
