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. 2014 Oct 28;64(4):1235–1248. doi: 10.2337/db14-1164

Figure 5.

Figure 5

Myeloid-restricted overexpression of Wnt5a promotes obesity-induced IR. Mye-Wnt5a-TG and WT mice (n = 8–10 per genotype) were fed an HFHS diet for 12 weeks. A: Western blot analysis of Wnt5a protein levels in epididymal WAT. Four independent pools of two mice per genotype were analyzed. Left: Densitometric quantification of the Wnt5a/GAPDH ratio. Right: Representative immunoblot. B: GTT and corresponding AUC analysis. C: ITT and corresponding AUC analysis. D: Serum insulin levels and (E) blood glucose levels in mice fasted 16 h or fed HFHS diet ad libitum.