. Author manuscript; available in PMC: 2016 May 1.

Published in final edited form as: Gen Comp Endocrinol. 2014 Sep 26;215:106–116. doi: 10.1016/j.ygcen.2014.09.010

Table 1. Models created for components of the RAS for human, mouse, and rat.

The sequence used for modeling the protein is shown for each with the UniProt code shown and amino acids listed below. The Z-score of each model was calculated using the YASARA2 force field. The % homology and carbon alpha (CA) RMSD were calculated following model alignment with the Mustang algorithm.

Protein	Model made with	Sequences used			Z- score			% Homology			CA RMSD (Å)
Protein	Model made with	Human	Mouse	Rat	Human	Mouse	Rat	Mouse to Human	Rat to Human	Rat to Mouse	Mouse to Human	Rat to Human	Rat to Mouse
ACE N-Terminal	pdb 2c6f	P12821 30-630	P094703 5-635	P47820 36-636	0	0.05	0.01	87.69	88.52	94.01	0.369	0.337	0.315

ACE C-Terminal	pdb 1o8a	P12821 631-1232	P094706 36-1237	P47820 637-1238	0.34	0.33	0.31	81.66	82.73	93.62	0.373	0.34	0.335

ACE2	pdb 1r42	Q9BYF1 18-708	Q8R0I01 8-740	Q5EGZ1 18-708	0.33	0.43	0.2	84.25	84.28	90.76	0.334	0.379	0.385

AGT	pdb 2x0b	P01019 34-485	P118592 5-477	P01015 25-477	−1.79	−2.03	−1.76	62.47	66.42	86.06	1.111	1.368	1.311

AT1a	I-TASSER	P30556 1-359	P29754 1-359	P25095 1-359	−2.23	−1.74	−1.78	94.38	95.21	98.61	0.871	0.837	0.321

AT1b	I-TASSER	-	P29755 1-359	P29089 1-359	−2.23	−1.81	−1.71	93.24	94.89	96.29	0.884	0.909	0.442

AT2	I-TASSER	P50052 1-363	P35374 1-364	P35351 1-365	−2.3	−2	−1.99	91.57	92.39	98.89	0.968	0.933	0.481

MAS	I-TASSER	P04201 1-325	P30554 1-325	P12526 1-325	−1.71	−1.46	−1.59	90.12	91.02	98.45	1.124	0.981	0.752

MRGD	I-TASSER	Q8TDS7 1-321	Q91ZB8 1-321	Q7TN41 1-319	−1.96	−1.52	−1.4	59.93	60.07	85.57	1.474	1.39	1.178

NEP	pdb 1r1h	P08473 52-750	Q61391 52-750	P07861 52-750	0.27	0.2	0.15	93.97	94.13	98.42	0.357	0.314	0.323

PRCP	pdb 3n2z	P42785 46-496	Q7TMR0 44-491	D4AA31 43-488	−0.3	−0.31	−0.29	80.27	80.49	90.7	0.308	0.333	0.315

Prorenin	pdb 4amt	P00797 24-406	P06281 22-402	P08424 27-402	−1.04	−1.24	−1.11	72.36	69.86	86.08	0.562	0.52	0.547

PRR	I-TASSER	O75787 \|17-350	Q9CYN9 18-350	Q6AXS4 18-350	−3.01	−3.15	−3.02	95.06	94.44	97.9	0.47	0.628	0.374

Renin1	pdb 2x0b	P00797 67-406	P06281 72-402	P08424 65-402	−0.88	−0.81	−1.05	71.73	67.67	85.54	0.625	0.479	0.608

Renin2	pdb 2x0b	-	P00796 64-401	-	-	−0.62	-	-	-	-	-	-	-