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. Author manuscript; available in PMC: 2016 Sep 4.
Published in final edited form as: Brain Res. 2014 Sep 26;1619:104–114. doi: 10.1016/j.brainres.2014.09.038

Figure 3. Descending propriospinal axons regenerate across the caudal graft-host interface and grew back into the distal host spinal cord.

Figure 3

(A) Schematic drawing shows the experimental strategy and how tissue was sampled. Note that a continuous growth permissive pathway was established by graft of Schwann cell over-expressing GDNF (SCs-GDNF) both in the lesion and caudal spinal cord to promote the axonal regrowth beyond the graft-host interface. (B) BDA-anterogradely labeled propriospinal axons (green, arrows) were found to penetrate through the distal graft-host interface (white dashed line) and to elongate within the distal host spinal cord only in the group injected with SCs-GDNF into the caudal host tissue. (C) The distal graft-host interface was demarcated by GFAP-labeled astrocytes (red). B&C Scale Bar=100µ m. Modified from Deng et al. (2013).