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Table 1.

Biodistribution of radioactivity (%ID/g tissue) in Ramos xenograft tumors and normal organs 24 hours after injection of radiolabeled antibody conjugates

[211At]1F5-B10 [125I]1F5-B10 [125I]1F5 [211At]HB8181-B10 [125I]HB8181-B10
Tumor 9.28 ± 1.85 7.53 ± 1.59 7.61 ± 2.09 3.46 ± 0.58 2.87 ± 3.55
Kidney 6.36 ± 0.54 4.24 ± 0.40 4.99 ± 0.60 5.85 ± 0.49 4.4 ± 0.22
Liver 9.41 ± 0.75 4.82 ± 0.38 4.71 ± 0.31 7.98 ± 0.29 5.49 ± .026
Lung 9.08 ± 1.1 7.21 ± 0.89 7.06 ± 1.41 9.09 ± 0.45 7.23 ± 0.44
Blood 20.23 ± 1.8 15.4 ± 0.98 19.07 ± 2.65 18.67 ± 0.71 15.51 ± 0.57
Muscle 1.31 ± 0.15 1.09 ± 0.11 1.3 ± 0.27 1.26 ± .019 1.09 ± 0.06