Table 2.

Pharmacokinetics

Patient #	Means			Oral versus infusion
	CLR (mL/min)	CLcrea (mL/min)	F reabsorption	T 1/2-oral (h)	T 1/2-inf (h)	F reabsorption-oral	F reabsorption-inf	CLR-oral (mL/min)	CLR-inf (mL/min)
1	121.1	166.8	0.27	9.2	21.2	0.23	0.31	127.6	114.6
2	54.2	60.0	0.10	16.1	11.1	0.28	−0.08	43.4	65.1
3	103.1	211.9	0.51	5.6	14.2	0.45	0.58	117.0	89.3
4	77.2	78.2	0.01	9.5	38.6	0.00	0.02	78.1	76.4
5	77.0	107.3	0.28	5.7	17.8	0.17	0.40	89.1	64.9
Mean (CI 95%)	86.5 (54.3–118.7)	124.9 (46.2–203.4)	0.24 (0.08–0.39)	9.22 (3.9–14.5)	20.6 (7.2–33.9)	0.23 (0.0–0.47)	0.25 (−0.09–0.58)	91.0 (49.6–132.5)	82.1 (56.3–107.8)