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. 2015 Apr 5;25(4):303–311. doi: 10.2188/jea.JE20140093

Table 2. Multivariate-adjusted eGFRcre according to tertile of serum (EPA+DHA):AA ratio in the Sasayama study, 2012–2013.

  Tertile of serum (EPA+DHA):AA P valuea

T1 T2 T3
Men        
 Number of participants 78 80 79  
 Range of (EPA+DHA):AA ratio 0.409–0.904 0.908–1.318 1.323–3.188  
 Sex- and age-adjusted mean eGFRcre (95% CI) 72.1 (68.8–75.4) 72.2 (69.1–75.4) 75.2 (72.0–78.5) 0.322
 Multivariate-adjusted mean eGFRcre (95% CI) (Model 1)b 71.3 (68.0–74.6) 72.5 (69.4–75.6) 75.8 (72.6–79.0) 0.139
 Multivariate-adjusted mean eGFRcre (95% CI) (Model 2)c 71.3 (68.0–74.6) 72.5 (69.4–75.6) 75.8 (72.6–79.0) 0.147
Women        
 Number of participants 103 104 105  
 Range of (EPA+DHA):AA ratio 0.338–0.925 0.929–1.282 1.283–2.777  
 Sex- and age-adjusted mean eGFRcre (95% CI) 73.2 (70.7–75.7) 73.2 (70.9–75.5) 73.0 (70.7–75.3) 0.989
 Multivariate-adjusted mean eGFRcre (95% CI) (Model 1)b 73.2 (70.6–75.7) 73.2 (70.9–75.5) 73.1 (70.7–75.4) 0.998
 Multivariate-adjusted mean eGFRcre (95% CI) (Model 2)c 73.2 (70.6–75.7) 73.1 (70.8–75.5) 73.1 (70.8–75.5) 1.000
Men and women combined        
 Number of participants 184 181 184  
 Range of (EPA+DHA):AA ratio 0.338–0.925 0.928–1.301 1.301–3.188  
 Sex- and age-adjusted mean eGFRcre (95% CI) 72.7 (70.7–74.7) 73.1 (71.2–75.0) 73.7 (71.8–75.6) 0.776
 Multivariate-adjusted mean eGFRcre (95% CI) (Model 1)b 72.3 (70.3–74.2) 73.3 (71.4–75.2) 74.0 (72.1–75.9) 0.507
 Multivariate-adjusted mean eGFRcre (95% CI) (Model 2)c 72.2 (70.2–74.2) 73.3 (71.4–75.1) 74.0 (72.1–75.9) 0.476

AA, arachidonic acid; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; GFR, glomerular filtration rate.

aP value for ANCOVA.

bMultivariate-adjusted (Model 1): eGFR adjusted for age, sex, BMI, hypertension, diabetes, HDL-C, LDL-C, medication for dyslipidemia, current smoking, and current drinking.

cMultivariate-adjusted (Model 2): eGFR adjusted for variables in model 1 plus log-transformed high-sensitivity C-reactive protein.