Table 3. Multivariate-adjusted eGFRcys according to tertile of serum (EPA+DHA):AA ratio in the Sasayama study, 2012–2013.
| Tertile of serum (EPA+DHA):AA | P valuea | |||
| T1 | T2 | T3 | ||
| Men | ||||
| Number of participants | 78 | 80 | 79 | |
| Range of (EPA+DHA):AA ratio | 0.409–0.904 | 0.908–1.318 | 1.323–3.188 | |
| Sex- and age-adjusted mean eGFRcys (95% CI) | 82.9 (79.5–86.3) | 89.5 (86.2–92.7) | 90.7 (87.4–94.1) | 0.003 |
| Multivariate-adjusted mean eGFRcys (95% CI) (Model 1)b | 83.9 (80.5–87.2) | 88.2 (85.0–91.3) | 91.0 (87.8–94.3) | 0.015 |
| Multivariate-adjusted mean eGFRcys (95% CI) (Model 2)c | 84.0 (80.6–87.3) | 88.2 (85.1–91.4) | 90.9 (87.7–94.1) | 0.017 |
| Women | ||||
| Number of participants | 103 | 104 | 105 | |
| Range of (EPA+DHA):AA ratio | 0.338–0.925 | 0.929–1.282 | 1.283–2.777 | |
| Sex- and age-adjusted mean eGFRcys (95% CI) | 89.6 (86.8–92.3) | 91.2 (88.7–93.8) | 91.2 (88.6–93.8) | 0.654 |
| Multivariate-adjusted mean eGFRcys (95% CI) (Model 1)b | 89.3 (86.6–91.9) | 91.5 (89.1–93.9) | 91.2 (88.8–93.7) | 0.466 |
| Multivariate-adjusted mean eGFRcys (95% CI) (Model 2)c | 89.2 (86.6–91.8) | 91.4 (89.0–93.8) | 91.4 (89.0–93.7) | 0.454 |
| Men and women combined | ||||
| Number of participants | 184 | 181 | 184 | |
| Range of (EPA+DHA):AA ratio | 0.338–0.925 | 0.928–1.301 | 1.301–3.188 | |
| Sex- and age-adjusted mean eGFRcys (95% CI) | 86.9 (84.7–89.0) | 90.7 (88.6–92.8) | 90.7 (88.5–92.7) | 0.023 |
| Multivariate-adjusted mean eGFRcys (95% CI) (Model 1)b | 86.9 (84.9–89.0) | 90.6 (88.7–92.6) | 90.6 (88.7–92.6) | 0.021 |
| Multivariate-adjusted mean eGFRcys (95% CI) (Model 2)c | 86.9 (84.9–88.9) | 90.5 (88.6–92.4) | 90.8 (88.9–92.7) | 0.016 |
AA, arachidonic acid; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; GFR, glomerular filtration rate.
aP value for ANCOVA.
bMultivariate-adjusted (Model 1): eGFR adjusted for age, sex, BMI, hypertension, diabetes, HDL-C, LDL-C, medication for dyslipidemia, current smoking, and current drinking.
cMultivariate-adjusted (Model 2): eGFR adjusted for variables in model 1 plus log-transformed high-sensitivity C-reactive protein.