Table 5. Multivariate-adjusted linear regression models^a between eGFR and serum PUFAs, including EPA+DHA, in the Sasayama study, 2012–2013.

	Independent variables
	eGFRcre		eGFRcys
	Standardized coefficients	P value	Standardized coefficients	P value
Model 1
Serum EPA+DHA	−0.012	0.815	0.097	0.025
Serum α-linolenic acid	0.088	0.191	0.015	0.797
Serum AA	0.008	0.862	−0.025	0.541
Serum linoleic acid	−0.144	0.064	−0.016	0.803
Model 2
Serum EPA+DHA	0.014	0.770	0.096	0.015
Serum n-6 PUFAb	−0.055	0.313	−0.022	0.622

AA, arachidonic acid; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; GFR, glomerular filtration rate; PUFA, polyunsaturated fatty acids.

^aRelationships between presented fatty acids and eGFR were evaluated by linear regression model after adjusting for age, sex, BMI, presence of hypertension and diabetes mellitus, serum HDL- and LDL- cholesterol level, medication for dyslipidemia, current smoking and drinking, and log-transformed C-reactive protein.

^bSerum n-6 PUFA: sum of linoleic acid, γ-linolenic acid, dihomo-γ-linolenic acid, and arachidonic acid.