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. 2015 Apr 5;25(4):303–311. doi: 10.2188/jea.JE20140093

Table 5. Multivariate-adjusted linear regression modelsa between eGFR and serum PUFAs, including EPA+DHA, in the Sasayama study, 2012–2013.

  Independent variables

eGFRcre eGFRcys


Standardized
coefficients
P value Standardized
coefficients
P value
Model 1        
 Serum EPA+DHA −0.012 0.815 0.097 0.025
 Serum α-linolenic acid 0.088 0.191 0.015 0.797
 Serum AA 0.008 0.862 −0.025 0.541
 Serum linoleic acid −0.144 0.064 −0.016 0.803
Model 2        
 Serum EPA+DHA 0.014 0.770 0.096 0.015
 Serum n-6 PUFAb −0.055 0.313 −0.022 0.622

AA, arachidonic acid; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; GFR, glomerular filtration rate; PUFA, polyunsaturated fatty acids.

aRelationships between presented fatty acids and eGFR were evaluated by linear regression model after adjusting for age, sex, BMI, presence of hypertension and diabetes mellitus, serum HDL- and LDL- cholesterol level, medication for dyslipidemia, current smoking and drinking, and log-transformed C-reactive protein.

bSerum n-6 PUFA: sum of linoleic acid, γ-linolenic acid, dihomo-γ-linolenic acid, and arachidonic acid.