Fig. 4.

Copy number changes of a panel of 36 genes in all 57 breast tumor samples grouped according to SBR grades or lymphovascular invasion status. The copy number status of 33 breast cancer driver genes and 3 genes (rows) identified in the present study (ADAMTS3, HSD17B12, and RERGL) is depicted for each tumor sample (columns) by colored squares: gains and amplifications are shown in blue and dark blue, respectively; losses and homozygous losses are red and dark red, respectively. a Schematic view showing the pattern of copy number changes of the panel of 36 genes in breast tumor samples grouped according to histologic grade. b Schematic view showing the pattern of copy number changes of the panel of 36 genes in breast tumors grouped according to lymphovascular invasion status