Fig. 5.

Cellular diagram of the network created by the Ingenuity Pathway Analysis based on interactions of the set of differentially expressed genes detected in histologic grade III breast tumors compared to grade I and grade II tumors. Red and green nodes represent, respectively, upregulated or downregulated genes (the intensity of the colors indicating the degree of deregulation) in grade III breast tumors in comparison to grade I and II tumors (Table 4); uncolored nodes represent genes automatically included in this network because they are biologically linked to the others based on scientific evidence. The functional categorization of this network was Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, with the S100A8 gene playing a central role