Table 3.
Frequency of gains affecting well-known breast cancer amplicons in high-risk breast carcinomas (histologic grade III and lymphovascular invasion positive)
| Known amplicon | Major gene | Total frequency (n affected) | Frequency among histologic grade III samples | Frequency among lymphovascular invasion positive samples |
|---|---|---|---|---|
| 8q24 | MYC | 38.6 % (22) | 81.8 % | 45.4 % |
| 8p12 | ZNF703/FGR1 | 31.6 % (18) | 72.2 % | 44.4 |
| 8p12 | FGFR1 | 29.8 % (17) | 64.7 % | 47.1 % |
| 19q12 | CCNE1 | 17.5 % (10) | 100 % | 55.5 % |
| 20q13.2 | ZNF217 | 14.0 % (8) | 62.5 % | 62.5 % |
| 11q13 | CCND1 | 14.0 % (8) | 50.0 % | 25.0 % |
In bold are indicated amplicons that were frequently detected (≥50 %) in tumors of each category