Fig 3.

NUDT15 variant was more frequent in East Asians but associated with mercaptopurine (MP) dose intensity regardless of ancestry. (A) T (risk) allele at rs116855232 was most common in individuals of East Asian descent followed by Hispanics, rare in Europeans, and not observed in Africans. T allele was consistently linked to lower MP dose intensity in (B) East Asians and (C) Hispanics; (D) similar trend was observed in Europeans. P values were estimated using linear mixed-effects model. Each box includes data between 25th and 75th percentiles, with horizontal line indicating median. Whiskers indicate maximal and minimal observations within 1.5× length of box.