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. 2015 Jan 26;33(11):1235–1242. doi: 10.1200/JCO.2014.59.4671

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© 2015 by American Society of Clinical Oncology

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Fig 4. — Combined effects of TPMT and NUDT15 variants on mercaptopurine (MP) intolerance. Each patient in (A) AALL03N1 and (B) St Jude cohorts was first assigned genetic risk score based on genotype at NUDT15 variant (rs116855232) and TPMT variants (rs1142345, rs1800462, and rs1800460; contributing to *2, *3A, *3B, and *3C). MP dose intensity decreased as genetic risk score increased in both cohorts. P value was estimated using Spearman correlation. Each box includes data between 25th and 75th percentiles, with horizontal line indicating median. Whiskers indicate maximal and minimal observations within 1.5× length of box. HET, heterozygous; HOM, homozygous; WT, wild type.