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Association of TPMT genotype (rs1142345) and thiopurine methyltransferase (TPMT) enzymatic activity. TPMT activity was measured from erythrocyte extracts for (A) 643 children on AALL03N1 protocol and (B) 311 patients in St Jude cohort. P value was estimated using linear regression with ancestry as covariate. Each box includes data between 25th and 75th percentiles, with horizontal line indicating median. Whiskers indicate maximal and minimal observations within 1.5× length of box.
