FIG 2.

Protective efficacy of cαStx2 in mice infected with B2F1. Str-treated mice were infected with B2F1 and then given no treatment, 0.9% saline solution, or cαStx2 administered intravenously at the listed doses (mg/kg) 24 (A), 48 (B), or 72 (C) h later. The median time to death for untreated mice (n = 30) was 6 days. n = 8 for the mice in the 0.9% saline solution and 0.001 and 0.01 mg/kg cαStx2 groups, 18 for the mice in the 0.1 mg/kg cαStx2 groups, and 10 for the mice in the 0.5 and 1.0 mg/kg cαStx2 groups. The statistics that follow represent comparisons at the same time point. The ^ symbol indicates P ≤ 0.005 compared to the 0.9% saline solution or 0.001 mg/kg cαStx2. The # symbol indicates P ≤ 0.01 compared to 0.01 mg/kg cαStx2. The + symbol indicates P = 0.015 compared to 0.9% saline solution. The = symbol indicates P = 0.048 compared to 0.001 mg/kg. The ▽ symbol indicates P = 0.01 compared to 0.001 mg/kg cαStx2.