TABLE 2.
Pharmacokinetic parameters for cαStx1 after intravenous administration to mice
| Parametera | Value |
|
|---|---|---|
| Males | Females | |
| Cmax (μg/ml) | 22.68 | 19.39 |
| Tmax (h) | 0b | 1 |
| AUC0–24 (μg · h/ml) | 206.4 | 224.4 |
| AUC0–336 (μg · h/ml) | 532.1 | 578.0 |
| AUC0–∞ (μg · h/ml) | 527.1 | 572.8 |
| ke (h−1) | 0.0133 | 0.014 |
| t1/2 (h) | 51.9 | 49.6 |
| Cl (ml/h · kg) | 1.91 | 1.75 |
| VZ (ml/kg) | 142.2 | 124.8 |
a
The definitions of the parameter terms are as follows: Cmax, maximum concentration of drug in serum; Tmax, time to maximum concentration of drug in serum; AUC0–24, area under the plasma concentration-time curve from 0 to 24 h; AUC0–336, area under the plasma concentration-time curve from 0 to 336 h; AUC0–∞, area under the plasma concentration-time curve from 0 to infinity; ke, elimination rate constant; t1/2, plasma half-life; Cl, drug clearance rate; VZ, volume of distribution based on terminal elimination phase.
b
The first sampling time was 5 min. Tmax was extrapolated to the zero time point because all values after 5 min were below that of the 5-min sample.