TABLE 2.
Descriptive statistics comparing survival between groups 2 through 5 (AdVAV) and group 6 (1:16 AVA)
| AdVAV group | Dose, vp (day[s] administered) | Estimated difference of survival proportions (95% CI)a | Upper limit of one-sided 95% CI for the estimated difference of survival proportionsa |
|---|---|---|---|
| 2 | 7.5 × 107 (0) | 0.06 (−0.10 to 0.23) | 0.20b |
| 3 | 1.5 × 109 (0) | 0.00 (−0.15 to 0.15) | 0.12c |
| 4 | 3.5 × 1010 (0) | −0.03 (−0.18 to 0.11) | 0.08c |
| 5 | 3.5 × 1010 (0, 28) | 0.00 (−0.15 to 0.15) | 0.12c |
a
Estimates are for the survival proportion induced by the 1:16 dilution of AVA (group 6) minus the survival proportion induced by the AdVAV group. CI, confidence interval. The 95% CIs were calculated using Newcombe's hybrid score interval with a continuity correction.
b
Value was rounded to the hundredth; actual value was greater than 0.20 (0.2039).
c
The upper limit of the one-sided 95% CI was less than 0.20; therefore, survival in the AdVAV group was noninferior to that in the 1:16 dilution AVA group (at the 0.05 level of significance).