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. 2015 Mar 26;2015:bav015. doi: 10.1093/database/bav015

Figure 1.

Figure 1.

The process of semantic reasoning using CRC as an example. The process involved three steps. We first utilized the OWL definition to define the CRC drugs in Protégé ontology editor. The ‘Equivalent to’ section shows the semantic definition of the CRC Drug class whereas the ‘Members’ section shows a partial list of all the drugs that are members of the class. Then, we employed DL rules to determine the inference path. This figure only shows the overall rule for inferring the possible genes that are relevant to CRC drugs. Additional rules were defined to infer CRC relevant pathways, SNPs and genes in the ontology. Finally, we used Pellet to infer potential CRC target genes. The ‘Equivalent to’ section shows a DL rule for finding the potential CRC target a gene whereas the ‘Members’ section (in yellow background) shows the inferred target genes.