Table 2.

KEGG pathways enriched significantly in the 113 genes

KEGG pathwaya	Adjusted P-valueb
Drug metabolism—other enzymesM	1.37 × 10−42
Metabolic pathwaysM	4.58 × 10−23
Metabolism of xenobiotics by cytochrome P450M	6.63 × 10−22
Steroid hormone biosynthesisM	1.73 × 10−21
Retinol metabolismM	9.48 × 10−21
Drug metabolism—cytochrome P450M	5.10 × 10−20
Bladder cancerD	5.21 × 10−17
Ascorbate and aldarate metabolismM	5.21 × 10−17
Pentose and glucuronate interconversionsM	3.73 × 10−16
ErbB signaling pathwayE	1.73 × 10−15
Porphyrin and chlorophyll metabolismM	6.00 × 10−15
Other types of O-glycan biosynthesisM	9.85 × 10−15
Bile secretionO	9.85 × 10−15
Starch and sucrose metabolismM	4.35 × 10−14
Pancreatic cancerD	4.78 × 10−13
ABC transportersE	5.31 × 10−13
Pathways in cancerD	7.13 × 10−12
Pyrimidine metabolismM	9.97 × 10−12
Prostate cancerD	6.39 × 10−9
Non-small cell lung cancerD	9.90 × 10−9
GliomaD	2.94 × 10−9
Endometrial cancerD	3.63 × 10−7
Renal cell carcinomaD	1.55 × 10−6
MelanomaD	1.60 × 10−6
Gap junctionC	4.99 × 10−6
Cytokine-cytokine receptor interactionE	7.82 × 10−6
GnRH signaling pathwayO	8.13 × 10−6
Focal adhesionC	1.65 × 10−5
Hepatitis CD	2.98 × 10−5
MAPK signaling pathwayE	7.00 × 10−4

^aThe capital letters beside the pathway names are the abbreviation of the KEGG category names at the first-level. C, cell communication, E, environmental information processing, D, human diseases, M, metabolism, O, organismal systems.

^bAdjusted P-value was corrected from nominal P-values by Benjamini–Hochberg multiple testing corrections.