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Survival plots for bigenic G37R/WT-SOD1:YFP and L126Z/WT-SOD1:YFP mice. The age at which PrP-SOD1-G37R-L110 mice reach a humane paralytic endpoint is shortened by either co-expressing WT-SOD1:YFP (n = 7) or intercrossing to produce mice homozygous for the transgene (n = 20) (A). Life expectancy of L126Z (L45) (n = 7) is not shortened by co-expressing WT-SOD1:YFP (n = 9) (B).
