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. 2015 Mar 24;108(6):1484–1494. doi: 10.1016/j.bpj.2015.02.012

Figure 1.

Figure 1

Ca2+ sensitivity of tension development in untreated and treated demembranated cardiac trabeculae. (A) Ca2+ sensitivity of tension in trabeculae treated with low levels of LKB1 complex activation of AMPK (open diamonds, rAMPK/LKB1lo) and high levels of LKB1 complex activation (open squares, rAMPK/LKB1hi) compared with untreated fibers (solid circles, untreated). (B) Ca2+ sensitivity of tension in trabeculae treated with only the LKB1 complex (open circles) compared with untreated fibers (solid circles). SL was set to 2.2 μm and all data were normalized to saturating Ca2+ (maximal) tension.