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. 2015 Jan 26;290(13):8232–8242. doi: 10.1074/jbc.M114.623074

FIGURE 6.

FIGURE 6.

Integrins α6β1 and αvβ3 mediated PDGF-BB-induced FAK activation and SMC migration. A, knockdown efficiency of integrins α6, β1, and β3 with specific integrin siRNAs was assessed in a Western blot analysis. Non, non-silencing siRNA. B, knockdown of expression of integrins α6, β1, and β3 with specific integrin siRNAs blocked PDGF-BB-induced FAK activation (1 h). C, knockdown of integrin α6, β1, and β3 expression with specific integrin siRNAs significantly inhibited PDGF-BB-induced SMC migration. **, p < 0.01 versus control (Con); ##, p < 0.01 versus the PDGF/non-silencing RNA group.