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Structural model of Hyp3 based on the A. terreus aristolochene synthase crystal structure. A, structural model of Hyp3 featuring the DDXX(D/E) motif (red) (N/D)XXSXXXE motif (orange), and Asn-136 and Phe-267 (cyan with side chain). B, aligned model of Hyp3 (blue) with substrate-bound aristolochene synthase (yellow). The FPP substrate of the aristolochene synthase is shown colored by element.
