Figure 1.

Clinical Findings of PLACK Syndrome

(A) Family pedigree of individual 1. The arrow indicates individual 1 (V-3).

(B) Individual 1 showed clinical features of generalized skin peeling, cheilitis, plantar keratoses on weight-bearing areas, blistering, leukonychia, and knuckle pads with multiple hyperkeratotic micropapules.

(C) Histopathology of skin biopsy from lower extremities of individual 1 demonstrated intraepidermal clefting with irregular acantholysis (hematoxylin-eosin staining; scale bar represents 50 μm).

(D) Similar clinical features were found in individual 2, including skin peeling, cheilitis, punctate keratoses of the soles, leukonychia, and knuckle pads with hyperkeratotic micropapules.