Table 2.
Demographic, clinical and pharmacological data for the 12 patients enrolled
| Patient | Age at enrollment (yr) | Disease | Thiopurine dose (mg/kg per day) | 5-ASA dose (mg/d) |
TGN concentration1 |
% TGN change | NAT1 status | |
| Before | After | |||||||
| 1 | 7.7 | CD | AZA 2.6 | 50 | 244 | 218 | -11% | Rapid |
| 2 | 17.3 | CD | AZA 2.2 | 50 | 2102 | 176 | -16% | Rapid |
| 3 | 17.8 | CD | AZA 1.6 | 50 | 2762 | 101 | -64% | Rapid |
| 4 | 14.7 | CD | 6MP 1.0 | 50 | 2882 | 1422 | -51% | Rapid |
| 5 | 10.4 | UC | 6MP 0.6 | 50 | 3102 | 2062 | -34% | Rapid |
| 6 | 14.5 | UC | 6MP 0.5 | 50 | 3302 | 1882 | -43% | Rapid |
| 7 | 11.9 | UC | 6MP 1.0 | 50 | 228 | 243 | +7% | Rapid |
| 8 | 17.4 | CD | AZA 2.2 | 50 | 2172 | 221 | +2% | Slow |
| 9 | 6.3 | UC | AZA 2.3 | 50 | 375 | 140 | -63% | Slow |
| 10 | 17.5 | UC | 6MP 1.0 | 50 | 6472 | 4012 | -38% | Slow |
| 11 | 17.3 | UC | 6MP 1.0 | 50 | 264 | 278 | +5% | Slow |
| 12 | 16.6 | CD | 6MP 0.5 | 50 | 501 | 2682 | -47% | Slow |
1
Pmol/8 × 108 erythrocytes;
2
This value is the average of two measurements. 5-ASA: 5-aminosalicylate; TGN: 6-thioguanine nucleotides; NAT1: N-acetyltransferase 1; CD: Crohn’s disease; UC: Ulcerative colitis; 6MP: 6-mercaptopurine; AZA: Azathioprine.