Figure 4.

Predicted open fraction ƒ_O(t) for a 1.5 s pulse of coapplied agonist and isoflurane; all at the same extremely high anesthetic concentration (c_an = 15 mM) but with varying (extremely low) agonist concentrations: c_ag = 0 μM (black line), 0.02 μM (black dashed line), 0.04 μM (black dotted line), 0.08 μM (black dot-dashed line), 0.15 μM (blue line), 0.3 μM (blue dashed line), 0.6 μM (blue dotted line), 1.25 μM (blue dot-dashed line), 2.5 μM (red line), 5 μM (red dashed line), and 100 μM (brown line). The rebound peak reaches its maximum at ∼5 μM. As is evident in the predicted trace at c_ag = 100 μM, an initial peak current is predicted to develop (with no effect on the rebound) and continues to grow as c_ag is further increased (not shown), as observed experimentally (e.g., see Fig. 3B in 12). To see this figure in color, go online.