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Gray matter atrophy in ALS versus controls. Selected axial plane reconstructions showing regions of reduced GM density in subjects with ALS, compared with controls. Regions of significantly reduced density (p ≤ 0.05, TFCE-corrected) are coloured in orange-yellow. Row A shows a comparison between all ALS subjects (n = 30) and controls (n = 17). Rows B and C show the patterns of atrophy in ALS subjects with a right-sided or left-sided index limb, respectively (n = 15 in each group).
