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. 2015 Mar 10;108(5):1038–1046. doi: 10.1016/j.bpj.2014.12.048

Figure 2.

Figure 2

(A) Recordings from a representative simulation in which (top) homosynaptic long-term depression (LTP) and (bottom) homosynaptic long-term potentiation (LTD) were induced by a θ-burst stimulation (TBS) of synapses placed on the apical trunk within 110 μm from the soma. Each point represents the percent change of the somatic (solid squares) and local (open circles) peak EPSP amplitude evoked by test pulses delivered to one random synapse before (t < 750 ms) and after (6000 < t < 7000 ms) a LTP or LTD conditioning period. In both cases, a depotentiation protocol was applied at t = 7000 ms for 40 s. (B) Heterosynaptic LTP, occurring in synapses that were not directly stimulated, as a function of the relative distance from a stimulated synapse. To see this figure in color, go online.