Table 3.
Brain regions showing significant relationships between NPs and brain glucose metabolism on FDG-PET
| Cluster extent | x* | y | z | Z † | Anatomical region | Brodmann area |
|---|---|---|---|---|---|---|
| Positive associations between FDG uptake and NP2 | ||||||
| 71 | 14 | 38 | −19 | 3.61 | Right Cerebrum, Frontal Lobe, Inferior Frontal Gyrus | 11 |
| 54 | −14 | 40 | −19 | 3.51 | Left Cerebrum, Frontal Lobe, Middle Frontal Gyrus | 11 |
| 40 | −25 | 48 | 30 | 3.48 | Left Cerebrum, Frontal Lobe, Superior Frontal Gyrus | 9 |
| 31 | 24 | 37 | 41 | 3.35 | Right Cerebrum, Frontal Lobe, Middle Frontal Gyrus | 8 |
| 39 | 24 | 14 | 45 | 3.32 | Right Cerebrum, Frontal Lobe, Middle Frontal Gyrus | 8 |
| Positive associations between FDG uptake and NP3 | ||||||
| 40 | −54 | 27 | 28 | 2.71 | Left Cerebrum, Frontal Lobe, Middle Frontal Gyrus | 46 |
| 47 | −2 | 26 | 31 | 2.57 | Left Cerebrum, Limbic Lobe, Cingulate Gyrus | 32 |
| Positive associations between FDG uptake and NP4 | ||||||
| 277 | 44 | −21 | −4 | 4.08 | Right Cerebrum, Temporal Lobe, Superior Temporal Gyrus | 22 |
| 259 | −15 | −3 | −17 | 3.64 | Left Cerebrum, Limbic Lobe, Parahippocampal Gyrus | 34 |
| −28 | −1 | −15 | 3.32 | Left Cerebrum, Limbic Lobe, Parahippocampal Gyrus, Amygdala | ||
| 278 | −36 | 14 | −22 | 3.55 | Left Cerebrum, Temporal Lobe, Superior Temporal Gyrus | 38 |
| 116 | −39 | −5 | −32 | 3.42 | Left Cerebrum, Temporal Lobe, Middle Temporal Gyrus | 21 |
| −34 | −8 | −29 | 3.27 | Left Cerebrum, Limbic Lobe, Uncus | 20 | |
| 141 | −6 | 13 | −10 | 3.41 | Left Cerebrum, Frontal Lobe, Medial frontal Gyrus | 25 |
| 59 | 23 | −43 | −5 | 3.39 | Right Cerebrum, Limbic Lobe, Parahippocampal Gyrus | 36 |
| 68 | −29 | −44 | −8 | 3.32 | Left Cerebrum, Limbic Lobe, Parahippocampal Gyrus | 37 |
| Negative associations between FDG uptake and NP5 | ||||||
| 333 | −47 | 8 | −35 | 3.52 | Left Cerebrum, Temporal Lobe, Middle Temporal Gyrus | 21 |
| −56 | −10 | −30 | 3.21 | Left Cerebrum, Temporal Lobe, Inferior Temporal Gyrus | 20 | |
| 235 | 36 | 20 | 37 | 3.33 | Right Cerebrum, Frontal Lobe, Middle frontal Gyrus | 9 |
| 43 | −48 | −44 | 39 | 2.87 | Left Cerebrum, Parietal Lobe, Inferior Lobule | 40 |
| 44 | 42 | 13 | −33 | 2.72 | Right Cerebrum, Temporal Lobe, Superior Temporal Gyrus | 38 |
*
Coordinates (x, y, z) from Talairach and Tournoux.
†
Z values at the peak of maximum significance at p<0.001, correcting for age and total caloric intake. Only contrasts yielding significant results are reported.
Abbreviations: NP1 = Vit B & minerals, NP2 = PUFA & Vit E, NP3 = Anti-oxidants & Fibers, NP4 = Vit B12 & D and zinc, NP5 = Fats and sodium