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. 2015 Feb 27;7:640–652. doi: 10.1016/j.nicl.2015.02.018

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© 2015 The Authors. Published by Elsevier Inc.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — Functional connectivity modeling of consistent striatal atrophy in HD. A) Location of the left (cluster maxima [x/y/z in MNI]: −12/12/6) and right (24/8/8) striatal seeds showing convergent evidence of atrophy as revealed by coordinate-based meta-analysis across voxel-based morphometry studies in HD (Dogan et al., 2013). B) Brain-wide co-activation maps of the seed regions as revealed by MACM: 1st panel: Brain-wide foci reported in BrainMap that featured the activation peaks closest to the respective seed voxels; these foci are modeled by 3D Gaussian reflecting uncertainty of their location using ALE meta-analysis. 2nd panel: above-chance convergence indicates significant co-activations with the respective seed region. 3rd panel: conjunction analysis showing common brain-wide co-activations between the left and right striatal seeds. C) 1st panel: resting-state connectivity for the left and right striatal seeds, respectively. 2nd panel: conjunction analysis showing common resting-state connectivity between the left and right striatal seeds.