Table 2.
Results of a Monte Carlo simulation describing the affect of lattice protein binding to the association rate of actin monomer binding to filaments
| α | LC (monomers) | |
|---|---|---|
| VASP | 9* (7–10)† | 160* (145–175)† |
| VASP ΔGAB | 5.1 (5.0–5.1) | 76 (74–76) |
| α-actinin | 0.4 (0.4–0.7) | 1 (1–11) |
| Filamin | 0.4 (0.2–0.8) | 11 (1–101) |
| NEM-myosin | 0.7 (0.3–0.9) | 11 (1–201) |
The binding of an actin-binding protein onto the lattice of a filament leads to changes (with magnitude α) in association kinetics that are propagated over a certain characteristic length LC, as a number of monomers.
*
The value obtained by minimizing the χ2.
†
The values in parenthesis represent the 68% confidence interval.