Table 2.
Cognitive (n=625) and Cerebral Hemodynamic (n=374) Measures According to Apolipoprotein E (APOE)-ε4 Status in the Maintenance of Balance, Independent Living, Intellect and Zest in the Elderly of Boston Study
| Measure | APOE-ε4− | APOE-ε4+ | P-Valueb |
|---|---|---|---|
| Least Square Mean (Standard Error)a | |||
| CO2 vasoreactivity, cm/s per mmHg/partial pressure of CO2mmHg x10−2 | 1.10 (0.05) | 0.95 (0.07) | .009 |
| Blood Flow Velocity, cm/s | 43.19 (1.26) | 42.13 (1.54) | .24 |
| Trail-Making Test, seconds | |||
| Part A | 62.5 (2.4) | 65.7 (3.0) | .36 |
| Part B | 165.4 (5.6) | 187.7 (7.0) | <.001 |
| Part B–A | 105.8 (4.8) | 124.7 (6.0) | <.001 |
| Hopkins Verbal Learning Test | |||
| Delayed recall | 5.8 (0.3) | 4.7 (0.3) | <.001 |
| Recognition | 11.6 (0.2) | 10.9 (0.2) | .006 |
a
Results obtained from generalized linear models adjusted for age, sex, race, educational level, body mass index, systolic blood pressure, and stroke.
b
Obtained from model comparing the two APOE groups adjusted for the same covariates. CO2=carbon dioxide.