Table 3.
Cognitive and Cerebral Hemodynamic Measures According to Apolipoprotein E (APOE)-ε4 and Hypertension Status in the Maintenance of Balance, Independent Living, Intellect and Zest in the Elderly of Boston Study
| Measure | Normotension and APOE-ε4−, n=126 | Hypertension or APOE- ε4+, n=391 | Hypertension and APOE- ε4+, n=108 | APOE by Hypertension, P-Valueb |
|---|---|---|---|---|
| Least Square Means (Standard Error)a | ||||
| Trail-Making Test, seconds | ||||
| Part A | 59.9 (3.4)c | 62.9 (2.4)c | 66.2 (3.3)c | .03 |
| Part B | 156.6 (7.7) | 169.7 (5.7) | 185.4 (7.6) | <.001 |
| Part B–A | 98.5 (6.5) | 109.6 (4.8) | 122.1 (6.4) | <.001 |
| Hopkins Verbal Learning Test | ||||
| Delayed recall | 6.1 (0.4)c | 5.6 (0.3)c | 4.8 (0.4) | <.001 |
| Recognition | 11.8 (0.3)c | 11.4 (0.2)c | 11.0 (0.3) | .002 |
| Blood flow velocity, cm/s | 42.6 (1.6)c | 42.9 (1.3)c | 42.0 (1.7)c | .61 |
| CO2 vasoreactivity, cm/s per mmHg/partial pressure of CO2mmHg x10−2 | 1.06 (0.07)c | 1.09 (0.05)c | 0.97 (0.07) | .01 |
a
Adjusted for age, sex, race, body mass index, stroke, systolic blood pressure, and educational level.
b
Obtained from models adjusted for the same covariates with the interaction parameter (APOE by hypertension).
c
Not significantly different from each other (after adjusting for pairwise multiple testing).